Concepedia

A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease

Shuxuan Huang, Zhi Chen, Binglin Fan, Yuan Chen, Liyuan Zhou, Bingjian Jiang, Haiyin Long, Xiaofeng Li, Yànhuá Lǐ

Journal of Neuroimmunology · 2021 · 77 citations · 26 references

DOI

Concepts

References

26

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

Yiqing Yan, Wei Jiang, Lei Liu et al. · Cell · 2015 · 1K citations · Full text

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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Rebecca C. Coll, James R. Hill, Christopher J. Day et al. · Nature Chemical Biology · 2019 · 996 citations · Full text

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Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Richard D. Gordon, Eduardo A. Albornoz, Daniel C. Christie et al. · Science Translational Medicine · 2018 · 890 citations

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Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Kazuhiro Imamura, Nozomi Hishikawa, Makoto Sawada et al. · Acta Neuropathologica · 2003 · 813 citations

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Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Colin Dempsey, Karen Bryson, Orla M. Finucane et al. · Brain Behavior and Immunity · 2016 · 568 citations

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