Concepedia

CNS Autoimmune Responses in BCMA-Deficient Mice Provide Insight for the Failure of Atacicept in MS

Gaurav Kumar, Zahra Maria, Uday Kohli, Agnieshka Agasing, James L. Quinn, Rose M. Ko, Scott S. Zamvil, Robert C. Axtell

Neurology Neuroimmunology & Neuroinflammation · 2021 · 14 citations · 29 references

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Abstract

BCMA has multifaceted roles during inflammation that affects therapeutic efficacies of anti-CD20 and TACI-Fc in EAE. Our results from BCMA-deficient mice provide insights into the failure of atacicept in MS.

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