Radical-mediated alkoxypolyhaloalkylation of styrenes with polyhaloalkanes and alcohols <i>via</i> C(sp³)–H bond cleavage

Abstract

We have developed a new radical-mediated alkoxypolyhaloalkylation of styrenes with polychloroalkanes and alcohols for the facile synthesis of complex polyhaloalkanes. 4-Methoxybenzenediazonium tetrafluoroborate is a good radical initiator for this transformation. This protocol is well applied to the late-stage functionalization of complex molecules, including vitamin E, estrone and cholesterol derivatives.