Crystal Growth & Design · 2021 · 32 citations · 28 references
PharmacyMedicinal ChemistryPharmaceuticsDrug DeliveryOral NanocarriersCocrystal FormationMedicinal Chemistry ApplicationsOral Drug BioavailabilityPharmaceutical Cocrystallization
New multicomponent solid forms of the nutraceutical pterostilbene have been discovered and characterized through experimental cocrystal screening. Among the coformers tested, picolinic acid formed a cocrystal with a 10-fold enhancement of oral bioavailability in rats, which converts the new cocrystal into a very promising candidate for new formulations of pterostilbene with improved performance.
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A short history of<i>SHELX</i>
George M. Sheldrick · Acta Crystallographica Section A Foundations of Crystallography · 2007 · 87.4K citations · Full text
Cocrystals of Quercetin with Improved Solubility and Oral Bioavailability
Adam J. Smith, P. Kavuru, Łukasz Wojtas et al. · Molecular Pharmaceutics · 2011 · 380 citations