Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer

PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition

Yasir H. Ibrahim, Celina García-García, Violeta Serra et al. · Cancer Discovery · 2012 · 611 citations · Full text

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Ashish Juvekar, Laura N. Burga, Hai Hu et al. · Cancer Discovery · 2012 · 475 citations · Full text

p110δ, a novel phosphoinositide 3-kinase in leukocytes

Bart Vanhaesebroeck, Melanie J. Welham, Kei Kotani et al. · Proceedings of the National Academy of Sciences · 1997 · 426 citations

Niraparib: First Global Approval

Lesley J. Scott · Drugs · 2017 · 170 citations

Regulatory Approval, First Global Approval, Preprint +2

Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair

Amit Kumar, Óscar Fernández-Capetillo, Ana C. Carrera · Proceedings of the National Academy of Sciences · 2010 · 162 citations · Full text