Processes · 2021 · 136 citations · 70 references
PharmacyPharmaceuticsPharmacokineticsDrug DeliveryPharmaceutical ManufacturingTargeted Drug DeliveryDrug Delivery EngineeringDrug Delivery SystemsDrug FormulationDrug Release From Dosage FormsDrug Release KineticsSustained Release FormulationsControlled Drug ReleaseControlled Release ProfilesDrug Release MechanismsDrug-delivery ApplicationsMedication Delivery SystemsPulsatile Drug ReleaseTargeted Release MechanismsTherapeutic Window Management
This work is aimed at providing a description of the complex world of drug carriers, starting from the description of this particular market in terms of revenue. Then, a brief overview of several types of conventional and innovative drug carrier systems has been included. The types of administration routes were also analyzed, with a critical and qualitative comment on drug release kinetics and drug profile shapes. Carriers were classified according to their ability to provide a prolonged and targeted release. The concept of the therapeutic window has been presented, providing advantages of having pulsed drug release to avoid side effects to target tissues. A critical comment on the use of conventional and innovative techniques for the production of drug carriers by large industrial companies has been proposed. As a final attempt for this work, an overall unique schematization of a drug carrier production process has been added, highlighting the necessity to create a strong double link among world-requested versatility of drug carriers for human applications and the newly developed industrial processes.
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New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Si‐Shen Feng · Nanomedicine · 2006 · 1.9K citations · Full text
Stimuli-responsive polymers and their applications
Menglian Wei, Yongfeng Gao, Xue Li et al. · Polymer Chemistry · 2016 · 1.3K citations · Full text
Natural Sciences, Materials Engineering, Materials Science +17