Science Translational Medicine · 2021 · 69 citations · 51 references
MedicineCell BiologyDevelopmental BiologyBone MetabolismCraniofacial DevelopmentStem Cell BiologyBone DevelopmentBone FormationBone Morphogenetic Protein SignalingCraniofacial MorphogenesisOsteogenesisSkeletal DevelopmentBmp In Bone FormationBmp Signal TransductionBmp-induced Cell DifferentiationBmpr1a SignalingBmpr1b SignalingCranial Bone DevelopmentEmbryologic Craniofacial DevelopmentStem Cell Specification
in mice caused precocious differentiation, leading to craniosynostosis initiated at the suture midline, which is the stem cell niche. We found that BMPR1A is a cell surface marker of human SuSCs. Using an ex vivo system, we showed that SuSCs maintained stemness properties for an extended period without losing the osteogenic ability. This study advances our knowledge base of congenital deformity and regenerative medicine mediated by skeletal stem cells.
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Causal analysis approaches in Ingenuity Pathway Analysis
A. Krämer, Jeff Green, Jack Pollard et al. · Bioinformatics · 2013 · 6.1K citations · Full text
Identification of the haematopoietic stem cell niche and control of the niche size
Jiwang Zhang, Chao Niu, Ling Ye et al. · Nature · 2003 · 2.9K citations · Full text