Stress‐Responsive Gene FK506‐Binding Protein 51 Mediates Alcohol‐Induced Liver Injury Through the Hippo Pathway and Chemokine (C‐X‐C Motif) Ligand 1 Signaling

Abstract

We identified an FKBP5-YAP-TEAD1-CXCL1 axis in the pathogenesis of ALD. Loss of FKBP5 ameliorates alcohol-induced liver injury through the Hippo pathway and CXCL1 signaling, suggesting its potential role as a target for the treatment of ALD.