Concepedia

Molecular mechanism underlying the hypolipidemic effect of Shanmei Capsule based on network pharmacology and molecular docking

Qian Wang, Lijing Du, Jiana Hong, Zhenlin Chen, Huijian Liu, Shasha Li, Xue Xiao, Shikai Yan

Technology and Health Care · 2021 · 25 citations · 41 references

DOIFull text

Open access

Abstract

The possible molecular mechanism mainly involved PPAR signaling pathway, Bile secretion and TNF signaling pathway via acting on MAPK8, PPARγ, MMP9, PPARα, FABP4 and NOS2 targets.

References

41

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Oleg Trott, Arthur J. Olson · Journal of Computational Chemistry · 2009 · 35.1K citations · Full text

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Kristina Schoonjans, Bart Staels, Johan Auwerx · Journal of Lipid Research · 1996 · 1.2K citations · Full text

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.

Kristina Schoonjans, Julia Peinado‐Onsurbe, Anne‐Marie Lefebvre et al. · The EMBO Journal · 1996 · 1.2K citations · Full text

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<i>ClusPro</i>: an automated docking and discrimination method for the prediction of protein complexes

Stephen R. Comeau, David Gatchell, Sándor Vajda et al. · Bioinformatics · 2003 · 861 citations · Full text