Concepedia

Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28

Bing Chen, Yuting Sang, Xiaojin Song, Dong Zhang, Lijuan Wang, Wenjing Zhao, Yiran Liang, Ning Zhang, Qifeng Yang

Theranostics · 2021 · 214 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

The present study demonstrates that CAFs promote breast cancer progression and metastasis via exosomal miR-500a-5p and indicate that inhibiting CAF-derived miR-500a-5p is an alternative modality for the treatment of breast cancer.

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