Pathology International · 2021 · 13 citations · 17 references
MedicineOncologyPathologyGastrointestinal OncologyMolecular OncologyNeoplasiaCancer Molecular PathologyColorectal CancerGene Fusions In CancerMalignant NeoplasmsOncogenic Fusion GenesReceptor Tyrosine Kinase OncogenesAdenosquamous CarcinomaAlk Fusion GenesImmunohistochemical DetectionImmunohistochemical StainingNtrk Fusion GenesOncogenic Fusion ProteinsReverse Transcription Polymerase Chain Reaction (Rt-pcr)Ros1 Fusion Genes
ALK, ROS1 and NTRK fusions are involved in the tumorigenesis of various organs, including colorectal cancer. This study aims to clarify the prevalence of these fusions in colorectal cancer in the Japanese population. Immunohistochemical analysis of 1012 specimens of colorectal cancer revealed two NTRK-positive cases (0.2%) whereas no ALK- or ROS1-positive cases were identified. Reverse transcription polymerase chain reaction (RT-PCR) detected an LMNA-NTRK1 fusion in a case of adenosquamous carcinoma and a TPM3-NTRK1 fusion in a case of tubular adenocarcinoma. Both NTRK1 fusion-positive cases lacked activating mutations in KRAS and BRAF and were mismatch repair-deficient with loss of MLH1 and PMS2 expression and MLH1 promoter methylation. Our results show that receptor tyrosine kinase fusions are rare but present in colorectal cancers in Japanese patients, with a prevalence similar to that reported in other countries.
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Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
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RET, ROS1 and ALK fusions in lung cancer
Kengo Takeuchi, Manabu Soda, Yuki Togashi et al. · Nature Medicine · 2012 · 1.3K citations