Phytochemical Profiling and Biological Activity of the Australian Carnivorous Plant, <i>Drosera magna</i>

Abstract

Phytochemical profiling was undertaken on the crude extracts of <i>Drosera magna</i> to determine the nature of the chemical constituents present. In total, three new flavonol diglycosides (<b>1</b>-<b>3</b>), one new flavan-3-ol glycoside (<b>4</b>), and 12 previously reported compounds of the flavonol (<b>5</b>, <b>9</b>), flavan-3-ol (<b>15</b>), flavanone (<b>8</b>), 1,4-napthoquinone (<b>6</b>, <b>7</b>, <b>13</b>, <b>14</b>), 2,3-dehydroxynapthalene-1,4-dione (<b>10</b>-<b>12</b>), and phenolic acid (<b>16</b>) structure classes were isolated and identified. Compounds <b>1</b>-<b>9</b>, <b>13</b>, <b>17</b>, and <b>18</b> were assessed for antimicrobial activity, with compounds <b>6</b>, <b>7</b>, <b>8</b>, and <b>9</b> showing significant activity. Compounds <b>1</b>, <b>2</b>, and <b>6</b> were also evaluated for anthelmintic activity against larval forms of <i>Hemonchus contortus</i>, with compound <b>6</b> being active.