Journal of Natural Products · 2021 · 10 citations · 16 references
Life SciencesBotanyPlant SciencesDrug DiscoveryPlant BiochemistryStructure-activity RelationshipsAnthelmintic PharmacologyMedicinal PlantsPlant-insect Chemical InteractionsStructure-activity Relationship AnalysisAnthelmintic AgentsBioactive ConstituentsBioactive Plant CompoundsBiological Activity FeaturesFlavonoid GlycosidesHaemonchus Contortus InfectionsPharmacological ScreeningPhytochemical Composition
Phytochemical profiling was undertaken on the crude extracts of Drosera magna to determine the nature of the chemical constituents present. In total, three new flavonol diglycosides (1–3), one new flavan-3-ol glycoside (4), and 12 previously reported compounds of the flavonol (5, 9), flavan-3-ol (15), flavanone (8), 1,4-napthoquinone (6, 7, 13, 14), 2,3-dehydroxynapthalene-1,4-dione (10–12), and phenolic acid (16) structure classes were isolated and identified. Compounds 1–9, 13, 17, and 18 were assessed for antimicrobial activity, with compounds 6, 7, 8, and 9 showing significant activity. Compounds 1, 2, and 6 were also evaluated for anthelmintic activity against larval forms of Hemonchus contortus, with compound 6 being active.
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Anna-Pelagia Magiorakos, Arjun Srinivasan, Roberta B. Carey et al. · Clinical Microbiology and Infection · 2011 · 14K citations
Helping Chemists Discover New Antibiotics
Mark A. T. Blaskovich, Johannes Zuegg, Alysha G. Elliott et al. · ACS Infectious Diseases · 2015 · 225 citations