Concepedia

Regulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ

Qiang Wang, Hao Wang, Qingxu Jing, Yang Yang, Dongbo Xue, Chenjun Hao, Weihui Zhang

Journal of Inflammation Research · 2021 · 25 citations · 42 references

Open access

Abstract

This study revealed that the exosomal miR-130a-3p/PPAR-γ axis participates in PSC activation and the mechanism of chronic pancreatitis (CP) with fibrosis, thus providing a potential new target for the treatment of chronic pancreatic fibrosis.

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