Concepedia

Silica-coated magnetic nanoparticles activate microglia and induce neurotoxic d-serine secretion

Tae Hwan Shin, Da Yeon Lee, Balachandran Manavalan, Shaherin Basith, Yun‐Cheol Na, Cheolho Yoon, Hyeon‐Seong Lee, Man‐Jeong Paik, Gwang Lee

Particle and Fibre Toxicology · 2021 · 31 citations · 43 references

DOIFull text

Open access

Abstract

MNPs@SiO<sub>2</sub>(RITC)-induced activation of microglia triggers excitotoxicity in neurons via D-serine secretion, highlighting the importance of neurotoxicity mechanisms incurred by nanoparticle-induced microglial activation.

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