Concepedia

Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart

Andrew N. Carley, Santosh K. Maurya, Matthew Fasano, Yang Wang, Craig H. Selzman, Stavros G. Drakos, E. Douglas Lewandowski

Circulation · 2021 · 120 citations · 37 references

DOIFull text

Open access

Abstract

SCFAs are more readily oxidized than ketones in failing hearts, despite both bypassing reduced CPT1 activity and represent an unexplored carbon source for energy production in failing hearts.

References

37

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice

Francine Z. Marques, Erin Nelson, Po‐Yin Chu et al. · Circulation · 2016 · 1K citations · Full text

Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)

Toshifumi Aoyama, Jeffrey M. Peters, Nobuko Iritani et al. · Journal of Biological Chemistry · 1998 · 855 citations · Full text

The Failing Heart Relies on Ketone Bodies as a Fuel

Grégory Aubert, Ola J. Martin, Julie L. Horton et al. · Circulation · 2016 · 686 citations · Full text

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

Kenneth Bedi, Nathaniel W. Snyder, Jeffrey Brandimarto et al. · Circulation · 2016 · 637 citations · Full text

Comprehensive quantification of fuel use by the failing and nonfailing human heart

Danielle Murashige, Cholsoon Jang, Michael D. Neinast et al. · Science · 2020 · 527 citations · Full text