European Journal of Clinical Microbiology & Infectious Diseases · 2021 · 35 citations · 13 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceBacteriologyMedical MicrobiologyAntibiotic ResistanceAntibiotic Resistance GeneticsAntimicrobial Resistance GenomicsBacterial IdentificationCarbapenem ResistanceResistance GenesCarbapenem-resistant EnterobacteralesCarbapenemase EnzymesEnterobacterales ResistanceEnzymesEscherichia ColiKlebsiella Pneumoniae CarbapenemaseMolecular CharacterizationMolecular Typing Of Resistant Isolates
Abstract One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). bla NDM-1 (45; 30.2%) and bla OXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%).
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Marya D. Zilberberg, Brian H. Nathanson, Kate Sulham et al. · BMC Infectious Diseases · 2017 · 227 citations · Full text
Gustavo Cerqueira, Ashlee M. Earl, Christoph M. Ernst et al. · Proceedings of the National Academy of Sciences · 2017 · 170 citations · Full text