Clinical and Experimental Vaccine Research · 2021 · 10 citations · 19 references
Natural SciencesImmunologyMaterials ScienceBiocompatibilityBiomaterialsNanomaterialsDrug EncapsulationNanobiomaterialsNanomaterials For Drug DeliveryNanomedicineNanoparticle FormulationsPolymeric NanoparticlesChitosanChitosan NanocarriersChitosan-based NanomaterialsChitosan-based Permeation EnhancementImmunogenicity EffectsNanomaterial ImmunogenicityNanoparticle Vaccine FormulationsTetanus Toxoid Vaccine
PURPOSE: Chitosan is a natural polymer that has excellent properties include biocompatibility, biodegradability, no cytotoxicity, high charge density, low cost, mucoadhesive, permeation enhancing (ability to cross tight junction), and immunomodulating ability that makes the spectrum of its applicability much broader. This study was conducted to investigate the stabilizing, preservative and immunogenicity properties of N-trimethyl chitosan nanospheres (N-TMCNS). MATERIALS AND METHODS: was compared with thimerosal formulated TT. RESULTS: more effective than thimerosal. CONCLUSION: Overall, the obtained results indicated that the N-TMCNS is one of the best stabilizer and preservative agent that can be used in the formulation of TT vaccine.
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Preparation and antibacterial activity of chitosan nanoparticles
Lifeng Qi, Zirong Xu, Xia Jiang et al. · Carbohydrate Research · 2004 · 1.8K citations