Concepedia

Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions

Núria Solà Tapias, Alexandre Denadai‐Souza, Claire Rolland-Fourcade, Muriel Quaranta-Nicaise, Catherine Blanpied, Marlène Marcellin, Anissa Edir, Corinne Rolland, Carla Cirillo, Gilles Dietrich,

Journal of Crohn s and Colitis · 2021 · 45 citations · 50 references

DOI

Abstract

Excessive ER stress in IECs caused an increased release of trypsin activity that, in turn, altered intestinal barrier function, promoting the development of inflammatory process.

References

50

Reinitiation involving upstream ORFs regulates <i>ATF4</i> mRNA translation in mammalian cells

Krishna M. Vattem, Ronald C. Wek · Proceedings of the National Academy of Sciences · 2004 · 1.7K citations · Full text

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Arthur Kaser, Ann–Hwee Lee, André Franke et al. · Cell · 2008 · 1.4K citations · Full text

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Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

Chad K. Heazlewood, Matthew Cook, Rajaraman Eri et al. · PLoS Medicine · 2008 · 687 citations · Full text

Role for protease activity in visceral pain in irritable bowel syndrome

Nicolas Cénac, Christopher N. Andrews, Marinella Holzhausen et al. · Journal of Clinical Investigation · 2007 · 577 citations · Full text

, , +17

Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice

Anne Bertolotti, Xiao-Zhong Wang, Isabel Novoa et al. · Journal of Clinical Investigation · 2001 · 400 citations · Full text