Concepedia

Nanoparticle-Mediated Delivery of Pitavastatin to Monocytes/Macrophages Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in <i>Apoe</i><sup>−/−</sup> Mice

Shunsuke Katsuki, Jun‐ichiro Koga, Tetsuya Matoba, Ryuta Umezu, Soichi Nakashiro, Kaku Nakano, Hiroyuki Tsutsui, Kensuke Egashira

Journal of Atherosclerosis and Thrombosis · 2021 · 23 citations · 38 references

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Abstract

These results suggest that Pitava-NPs inhibit AAA formation associated with reduced macrophage accumulation and MCP-1 expression. This clinically feasible nanomedicine could be an innovative therapeutic strategy that prevents devastating complications of AAA.

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