Concepedia

Publication | Open Access

Mast cell‐derived serotonin enhances methacholine‐induced airway hyperresponsiveness in house dust mite‐induced experimental asthma

DOIFull Paper Access

49

Citations

35

References

2021

Year

Erika Méndez-Enríquez, Abigail Alvarado-Vázquez, Willem Abma, Oscar E. Simonson, Sergey Rodin, Thorsten B. Feyerabend, Hans‐Reimer Rodewald, Andreï Malinovschi, Christer Janson, Mikael Adner,
Allergy

Abstract

Methacholine activates mast cells to release 5-HT, which by acting on 5-HT<sub>2A</sub> receptors enhances bronchoconstriction and AHR. Thus, M3-directed asthma treatments like tiotropium may also act by targeting mast cells.

References

YearCitations

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