Theranostics · 2021 · 47 citations · 37 references
Life SciencesCancer BiologyMolecular BiologyEpigeneticsGene ExpressionMolecular Cell BiologyCancer EpigeneticsCancer TranscriptomicsEpigenetic Alterations In CancerEpigenetic Regulation In CancerHistone ModificationsSignal Transduction In CancerEpigenetic Drug ResistanceEpigenetic DysregulationHistone Demethylase InhibitionHistone DemethylasesKinase Inhibitor ResistanceMolecular Drug ResistanceTherapeutic Tyrosine Kinase InhibitorsTranscriptional Upregulation
Contrary to its reported role as a tumor suppressor and independent of its demethylase function, KDM6A promotes imatinib-resistance in CML cells. The identification of the KDM6A/YY1/TRKA axis as a novel imatinib-resistance mechanism represents an unexplored avenue to overcome TKI resistance in CML.
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Genome engineering using the CRISPR-Cas9 system
F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
Gillian L. Dalgliesh, Kyle Furge, Chris Greenman et al. · Nature · 2010 · 1.2K citations · Full text
Extraction, purification and analysis of histones
David Shechter, Holger L. Dormann, C. David Allis et al. · Nature Protocols · 2007 · 1.1K citations