Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi, Steven O’Day, David F. McDermott, +26

New England Journal of Medicine

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov, Matthew R. Jones, Andrew D. Rouillard, +11

Nucleic Acids Research

GeneticsMolecular BiologyCurated Gene SetsGenomicsGene Recognition +18

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell, Davide Cacchiarelli, Jonna Grimsby, +7

Nature Biotechnology

Pattern FormationDevelopmental BiologyCell DivisionCell InteractionSingle-cell Biology +10

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

Jonathan E. Rosenberg, Jean Hoffman‐Censits, Tom Powles, +28

The Lancet

UrologyMetastatic Urothelial CarcinomaGenitourinary CancerMedicineImmune Checkpoint Inhibitor +6

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor, Andrew J. Rech, Amit Maity, +22

Nature

Cancer ImmunosurveillanceMedicineImmunologyNon-redundant Immune MechanismsImmune Checkpoint Inhibitor +7

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

Liufu Deng, Hua Liang, Byron Burnette, +4

Journal of Clinical Investigation

Ir TreatmentRadiation OncologyTumor ImmunologyCancer ImmunosurveillanceRadiation Therapy +13

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Claire Vanpouille‐Box, Amandine Alard, Molykutty J. Aryankalayil, +7

Nature Communications

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Alexander C. Huang, Michael A. Postow, Robert J. Orlowski, +31

Nature

Burden RatioCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +6

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Lei Zhang, Ziyi Li, Katarzyna M. Skrzypczynska, +26

Cell

Tumor BiologyMedicineColorectal CancerSingle-cell GenomicsColon Cancer +9

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Chi Ma, Miaojun Han, Bernd Heinrich, +20

Science