HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

Nadine Laguette, Bijan Sobhian, Nicoletta Casartelli et al. · Nature · 2011 · 1.5K citations

Human Retrovirus, Immunology, Antiviral Response +6

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Kasia Hrecka, Caili Hao, Magda Gierszewska et al. · Nature · 2011 · 1.2K citations

Inflammation, Medicine, Human Retrovirus +10

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Qian Zhang, Kai Zhao, Qicong Shen et al. · Nature · 2015 · 775 citations

Inflammation, Cytokine, Inflammatory Disease +8

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

Matthew F. Barber, Eriko Michishita-Kioi, Yuanxin Xi et al. · Nature · 2012 · 604 citations

Transcription Regulation, H3k18 Deacetylation, Molecular Biology +1

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

Carine Van Lint, Stéphane Emiliani, Mélanie Ott et al. · The EMBO Journal · 1996 · 576 citations · Full text

Chromatin, Transcriptional Regulation, Transcriptional Activation +14