Isotype-specific Antibody Responses to <i>Mycobacterium avium paratuberculosis</i> Antigens Are Associated With the Use of Biologic Therapy in Inflammatory Bowel Disease

Abstract

Extensive assays for serological response to MAP were evaluated using stringent criteria for reliability. Increased IgA and IgM response to MAP antigens was seen in patients exposed to biologic therapy, but no genetic determinants underlying this humoral response were found.