JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca ²⁺ ] _SR Leak-Load Relationship

Abstract

We have identified a novel JNK2-induced activation of SERCA2. The dual action of JNK2 in CaMKII-dependent arrhythmic SR Ca²⁺ leak and a CaMKII-independent uptake exacerbates atrial arrhythmogenicity, while helping to maintain normal levels of Ca²⁺ transients and heart function. JNK2 modulation may be a novel therapeutic target for atrial fibrillation prevention and treatment.