Minocycline prevents the inflammatory response after retinal detachment, where microglia phenotypes being regulated through A20

Minocycline selectively inhibits M1 polarization of microglia

Kazuyoshi Kobayashi, Shiro Imagama, Tomohiro Ohgomori et al. · Cell Death and Disease · 2013 · 731 citations · Full text

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

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Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

Mi‐Hyang Cho, Kwangmin Cho, Kang Hoe-Jin et al. · Autophagy · 2014 · 377 citations · Full text

Mitophagy, Immunology, Immune Regulation +22

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

Bao Duong, Michio Onizawa, Juan A. Osés-Prieto et al. · Immunity · 2015 · 264 citations · Full text

Inflammation, Cytokine, Inflammatory Disease +14

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie Voet, Conor Mc Guire, Nora Hagemeyer et al. · Nature Communications · 2018 · 236 citations · Full text