Journal of Turkish Society of Obstetric and Gynecology · 2020 · 20 citations · 9 references
Life SciencesGynecologyImmunologyImmunopathologyReproductive ImmunologyReproductive MedicineDecidual ImmunologyEndometrial ImmunologyGynecologic PathologyImplantation ImmunologyMenstrual CycleNatural Killer Cell BiologyDecidual Natural Killer CellsEndometrial Immune Cell PopulationsEndometrial Innate ImmunityImplantation Failure PathologyLeukocyte-endometrial InteractionsRecurrent Implantation Failure EvaluationRecurrent Implantation Failure ImmunologyUterine Natural Killer Cell Biology
OBJECTIVE: Implantation failure is a multifactorial problem of reproductive medicine. However, the mechanism of this process is still not fully understood. There is increasing evidence that these cases of recurrent implantation failure might have an immunologic background. Uterine natural killer (NK) cells provide immune-modulation at the interface between maternal decidua and the trophoblast. The aim of this study to evaluate whether there was a significant difference in the number of endometrial CD56+ NK between women with a history of recurrent implantation failure and women who had a live birth. MATERIALS AND METHODS: day of the menstrual cycle. RESULTS: in the control group. There was a statistically significant difference between the two groups (p=0.003). CONCLUSION: Implantation failure is a multifactorial problem of reproductive medicine. The results of our study suggest that uterine NK play a role in the progress of normal pregnancy and reduced uterine NK cell numbers were associated with implantation failure.
9
Comparative studies of human FcRIII-positive and negative natural killer cells.
Arnon Nagler, Lewis L. Lanier, Steven E. Cwirla et al. · The Journal of Immunology · 1989 · 683 citations · Full text