Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death

Disruption of CREB function in brain leads to neurodegeneration

Theo Mantamadiotis, Thomas Lemberger, Susanne C. Bleckmann et al. · Nature Genetics · 2002 · 688 citations · Full text

Neurodegenerative Diseases, Creb Function, Neurological Function +6

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Sung‐Wuk Jang, Xia Liu, Manuel Yepes et al. · Proceedings of the National Academy of Sciences · 2010 · 665 citations · Full text

Brain-derived Neurotrophic Factor, Neurodegenerative Diseases, Selective Trkb Agonist +15

Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

Ramiro D. Almeida, Bruno Manadas, Carlos V. Melo et al. · Cell Death and Differentiation · 2005 · 572 citations · Full text

Neurodegenerative Diseases, Signal Transduction, Medicine +14

Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease

Josep M. Canals, José Ramón Pineda, Jesús F. Torres-Peraza et al. · Journal of Neuroscience · 2004 · 345 citations · Full text

Striatal Dopamine, Amyotrophic Lateral Sclerosis, Medicine +15

Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease.

Andrea Ciarmiello, Milena Cannella, Secondo Lastoria et al. · PubMed · 2006 · 299 citations