Concepedia

PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

Antonius A. de Waard, Tamara Verkerk, Marlieke L.M. Jongsma, Kelly Hoefakker, Sunesh Sethumadhavan, Carolin Gerke, Sophie Bliss, Xiangrui Kong, George M. C. Janssen, Arnoud H. de Ru,

European Journal of Immunology · 2020 · 10 citations · 9 references

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Abstract

A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.

References

9

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Moshe Sade-Feldman, Yunxin J. Jiao, Jonathan Chen et al. · Nature Communications · 2017 · 967 citations · Full text

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues

Ian A. York, Shih‐Chung Chang, Tomo Šarić et al. · Nature Immunology · 2002 · 504 citations · Full text

, , +2

Simultaneous alignment and clustering of peptide data using a Gibbs sampling approach

Massimo Andreatta, Ole Lund, Morten Nielsen · Bioinformatics · 2012 · 155 citations · Full text

Functional Relationship between Calreticulin, Calnexin, and the Endoplasmic Reticulum Luminal Domain of Calnexin

Ursula Danilczyk, Myrna F. Cohen-Doyle, David B. Williams · Journal of Biological Chemistry · 2000 · 110 citations · Full text

Uncovering the Peptide-Binding Specificities of HLA-C: A General Strategy To Determine the Specificity of Any MHC Class I Molecule

Michael Rasmussen, Mikkel Harndahl, Anette Stryhn et al. · The Journal of Immunology · 2014 · 85 citations · Full text

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