Endothelial S1P ₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke

Abstract

This study provides genetic evidence to support a pivotal role for the endothelium in maintaining perfusion and microvascular patency in the ischemic penumbra that is coordinated by S1P signaling and can be harnessed for neuroprotection with blood-brain barrier-penetrating S1P₁ agonists.