Protective effects of Phlomis umbrosa extract on a monosodium iodoacetate–induced osteoarthritis model and prediction of molecular mechanisms using transcriptomics

Abstract

Based on the results of gene expression profiling, this study highlighted the molecular mechanisms underlying the effects of PUE in MIA-induced OA rats. The findings provide novel insight into the mechanisms by which PUE treatment-induced gene expression changes may influence OA disease progression. Taken together, the results suggest that PUE may be used as a source of therapeutic agents for OA.