Proceedings of the National Academy of Sciences · 2020 · 131 citations · 41 references
Veterinary MedicineInfectious DiseasesZoologyBiological ControlPrion DiseasesZoonotic Disease EpidemiologyAnimal Prion DiseasesChronic Wasting DiseaseDisease EcologyWildlife Disease EpidemiologyWildlife Disease SurveillanceZoonotic Disease ComparisonsCervid EcologyContagious Disease ControlContagious Disease SpreadPrion EpidemiologyPrion Strain CharacterizationPrion Surveillance
), we found that prions causing CWD in Norway induced incubation times, neuropathology, regional deposition of misfolded prion protein aggregates in the brain, and size of their protease-resistant core, different from those that characterize North American CWD. These findings show that CWD prion strains affecting Norwegian cervids are distinct from those found in North America, implying that the highly contagious North American CWD prions are not the proximate cause of the newly discovered Norwegian CWD cases. In addition, Norwegian CWD isolates showed an unexpected strain variability, with reindeer and moose being caused by different CWD strains. Our findings shed light on the origin of emergent European CWD, have significant implications for understanding the nature and the ecology of CWD in Europe, and highlight the need to assess the zoonotic potential of the new CWD strains detected in Europe.
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Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent
M. E. Bruce, Robert Will, James W. Ironside et al. · Nature · 1997 · 2K citations