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Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research

Vitro-in Vivo ExtrapolationTranslational MedicineHepatologyMedicineLiver PhysiologyDiscovery ResearchTranslational ResearchHepatotoxicityLiver DiseaseProtein TransportPharmacologyCell BiologyDrug-induced Liver InjuryDrug Discovery