Synthesis of Benzothiadiazine-1-oxides by Rhodium-Catalyzed C−H Amidation/Cyclization

Abstract

A rhodium-catalyzed C−H amidation/cyclization sequence provides benzothiadiazine-1-oxides from sulfoximines and 1,4,2-dioxazol-5-ones in good yields. The reaction is characterized by a high functional group tolerance and, in contrast to most previous transformations of this type, is well-suited for S-alkyl-S-aryl-substituted sulfoximines.