A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir et al. · Diabetes · 2003 · 4K citations

Medicine, Endocrinology, Physiology +17

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

Julio F. Turrens, Adolfo Alexandre, Albert L. Lehninger · Archives of Biochemistry and Biophysics · 1985 · 1.2K citations

Life Sciences, Biochemistry, Physiology +15

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues

Slgurd Lenzen, Jens Drinkgern, Markus Tiedge · Free Radical Biology and Medicine · 1996 · 1.2K citations

Life Sciences, Molecular Biology, Molecular Genetics +16

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

Philippe Ravassard, Yasmine Hazhouz, Sèverine Pechberty et al. · Journal of Clinical Investigation · 2011 · 587 citations · Full text

Life Sciences, Biotechnology, Cell Biology +17

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

Annette Schürmann, Aisling Mooney, Luraynne C. Sanders et al. · Molecular and Cellular Biology · 2000 · 352 citations · Full text

Life Sciences, Cell Biology, Apoptosis +16