<p>Down-Regulation of Hypoxia-Inducible Factor-1α and Downstream Glucose Transporter Protein-1 Gene by β-elemene Enhancing the Radiosensitivity of Lung Adenocarcinoma Transplanted Tumor</p>

Abstract

β-elemene exhibits a radiosensitizing effect on A549 cell xenograft tumor. The underlying molecular mechanism is probably associated with the down-regulation of <i>HIF-1α</i> and <i>GLUT-1</i> expression, suggesting that β-elemene may directly or indirectly inhibit the expression of <i>HIF-1α</i> and <i>GLUT-1</i>. There is a positive significant correlation between expression of <i>HIF-1α</i> and <i>GLUT-1</i>. <i>HIF-1α</i> and downstream <i>GLUT-1</i> could be used as a new target for the radiosensitization of NSCLC.