Concepedia

IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells

Zhiwu Jiang, Rui Liao, Jiang Lv, Shanglin Li, Diwei Zheng, Le Qin, Di Wu, Suimin Chen, Youguo Long, Qiting Wu,

Leukemia · 2020 · 51 citations · 42 references

Concepts

Life SciencesImmunologyOncologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCell-mediated ImmunityImmune Cell SignalingT Cell ActivationT Cell BiologyT Cell Responses To TumorsCar T-cell ExhaustionCytokine-driven T Cell DifferentiationCytokine-mediated T Cell ActivationCytokine-mediated T Cell ResponsesT Cell Cytokine SignalingT-cell Activation By CytokinesT-cell Modulation

References

42

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

Shannon L. Maude, Theodore W. Laetsch, Jochen Buechner et al. · New England Journal of Medicine · 2018 · 5.6K citations · Full text

Medicine, Hematology, Oncology +17

Current concepts in the diagnosis and management of cytokine release syndrome

Daniel W. Lee, Rebecca Gardner, David Porter et al. · Blood · 2014 · 2.8K citations

Life Sciences, Immunology, Molecular Medicine +14

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Marco L. Davila, Isabelle Rivière, Xiuyan Wang et al. · Science Translational Medicine · 2014 · 2.5K citations · Full text

Medicine, Hematology, Oncology +17

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial

Frederick L. Locke, Armin Ghobadi, Caron A. Jacobson et al. · The Lancet Oncology · 2018 · 2.3K citations

Medicine, Oncology, Pharmacology +12

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Christine E. Brown, Darya Alizadeh, Renate Starr et al. · New England Journal of Medicine · 2016 · 1.8K citations · Full text

Medicine, Immunology, Oncology +17