Concepedia

UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway.

Jiangning Li, Zheng Yang, Xiaofeng Li, Dong Xue, Weiyan Chen, Zhongying Guan, Chong Zhang

PubMed · 2020 · 28 citations · 26 references

Full text

Open access

Abstract

UCHL3 plays an oncogenic role through the AKT/mTOR/SOX12 axis and can be considered as a potential target for therapy and CRC prognostic biomarker.

References

26

The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties

Peter Dy, Alfredo Penzo‐Méndez, Hongzhe Wang et al. · Nucleic Acids Research · 2008 · 239 citations · Full text

, , +15

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors

Dongshi Chen, Jingshan Tong, Liheng Yang et al. · Proceedings of the National Academy of Sciences · 2018 · 176 citations · Full text

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation

Jingshan Tong, Shuai Tan, Fangdong Zou et al. · Oncogene · 2016 · 167 citations · Full text

, , +11

Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

Jingshan Tong, Peng Wang, Shuai Tan et al. · Cancer Research · 2017 · 156 citations · Full text

Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up‐regulating Twist1 and FGFBP1

Wenjie Huang, Zhangqian Chen, Xin Shang et al. · Hepatology · 2015 · 124 citations