Visible-Light-Induced Regio- and Stereoselective C(sp²)–H Trifluoroethylation of Enamides with 2,2,2-Trifluoroethyl Iodide

Abstract

A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.