Novel Oncolytic Herpes Simplex Virus 1 VC2 Promotes Long-Lasting, Systemic Anti-melanoma Tumor Immune Responses and Increased Survival in an Immunocompetent B16F10-Derived Mouse Melanoma Model

Ifeanyi K. Uche, Natalie W. Fowlkes, Luan D. Vu, Tatiane Terumi Negrão Watanabe, Mariano Carossino, Rafiq Nabi, Fábio Del Piero, Jared S. Rudd, Konstantin G. Kousoulas, Paul J. F. Rider

Journal of Virology · 2020 · 24 citations · 39 references

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Abstract

T cells for efficacy, our model will enable study of the immunological correlates of protection for VC2 oncolytic virotherapy and oncolytic virotherapy in general. Understanding the mechanisms of efficacious oncolytic virotherapy will inform the rational design of improved oncolytic virotherapies.

References

39