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Brain differences in the prefrontal cortex, amygdala, and hippocampus in youth with congenital adrenal hyperplasia
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2020
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NeuropsychologyAdrenal Androgen ProductionDevelopmental Cognitive NeuroscienceBrain DifferencesPrefrontal CortexNeuroendocrinologyGynecologyNeuropsychiatryGlucocorticoidSocial SciencesReproductive EndocrinologyHormonal ImbalancesAdhdAdrenal GlandCongenital Adrenal HyperplasiaCognitive DevelopmentNeurologyAbnormal DevelopmentBrain PathologyNeuropathologyCognitive NeuroscienceNeuropsychological FunctioningPsychiatryBrain StructureGlucocorticoid ReceptorsAdrenal DiseaseEndocrinologyDevelopmental BiologyAdrenal HealthPhysiologyNeuroendocrine DisorderNeuroscienceBiological PsychiatryMedicine
Classical congenital adrenal hyperplasia (CAH) is characterized by impaired glucocorticoid, and often also mineralocorticoid, secretion and increased adrenal androgen production (1). Given the widespread expression of androgen and glucocorticoid receptors throughout the brain (2, 3), there has been a growing interest in understanding how hormonal imbalances related to CAH may impact distinct subregions of the developing brain (4).