Concepedia

Design, synthesis, molecular simulation, and biological activities of novel quinazolinone-pyrimidine hybrid derivatives as dipeptidyl peptidase-4 inhibitors and anticancer agents

Leila Emami, Zahra Faghih, Amirhossein Sakhteman, Zahra Rezaei, Zeinab Faghih, Farnaz Salehi, Soghra Khabnadideh

New Journal of Chemistry · 2020 · 48 citations · 39 references

DOI

Concepts

Abstract

Twelve novel quinazolinone–pyrimidine hybrids were synthesized, of which some of them showed dual functions as DPP-4 inhibitors and anti-cancer agents.

References

39

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Dalila Darmoul, Michel Lacasa, Laurent Baricault et al. · Journal of Biological Chemistry · 1992 · 176 citations · Full text

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The Protease Complex Consisting of Dipeptidyl Peptidase IV and Seprase Plays a Role in the Migration and Invasion of Human Endothelial Cells in Collagenous Matrices

Giulio Ghersi, Qiang Zhao, Monica Salamone et al. · Cancer Research · 2006 · 160 citations · Full text

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