Concepedia

Publication | Open Access

Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone

DOIFull Paper Access

14

Citations

38

References

2020

Year

Mareike Gierhardt, Oleg Pak, Akylbek Sydykov, Simone Kraut, Julia Schäffer, Claudia Garcia, Christine Veith, Esraa M. Zeidan, Monika Brosien, Karin Quanz,
Cardiovascular Research

Abstract

We conclude that p66shc specifically regulates the pulmonary vascular tone, while CypD also affects systemic pressure. However, only CypD acts via regulation of mPTP opening and mitochondrial calcium regulation.

References

YearCitations

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