Science Advances · 2020 · 154 citations · 43 references
Natural SciencesBiophysicsCell BiologyBiomedical ImagingBiomedical OpticsBiophotonicsCellular ImagingCerebral Blood FlowLight-tissue InteractionRed Blood Cell PhysiologyScattering TheoryTissue Optical PropertiesBlood Flow MeasurementCerebral Blood Flow QuantificationLight ScatteringRed Blood Cell DynamicsScattering-based Optical Imaging
We introduce dynamic light scattering imaging (DLSI) to enable the wide-field measurement of the speckle temporal intensity autocorrelation function. DLSI uses the full temporal sampling of speckle fluctuations and a comprehensive model to identify the dynamic scattering regime and obtain a quantitative image of the scatterer dynamics. It reveals errors in the traditional theory of laser Doppler flowmetry and laser speckle contrast imaging and provides guidance on the best model to use in cerebral blood flow imaging.
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