SIAM Journal on Control and Optimization · 2022 · 18 citations · 33 references
Public HealthInfectious Disease ControlInfectious DiseasesCommunicable Disease ControlEpidemiologyPublic Health SurveillanceAge DifferencesDisease ControlAge Distribution In CompartmentsAge-structured Compartmental ModelsCompartmental Model ConstructionSocial Distancing BehaviorTesting
In this paper, we provide insights on how much testing and social distancing is required to control COVID-19.To this end, we develop a compartmental model that accounts for key aspects of the disease: incubation time, age-dependent symptom severity, and testing and hospitalization delays; the model's parameters are chosen based on medical evidence, and, for concreteness, adapted to the German situation.Then, optimal mass-testing and age-dependent social distancing policies are determined by solving optimal control problems both in open loop and within a model predictive control framework.We aim to minimize testing and/or social distancing until herd immunity sets in under a constraint on the number of available intensive care units.We find that an early and short lockdown is inevitable but can be slowly relaxed over the following months.
33
Virological assessment of hospitalized patients with COVID-2019
Roman Wölfel, Victor M. Corman, Wolfgang Guggemos et al. · Nature · 2020 · 7.2K citations · Full text
The Mathematics of Infectious Diseases
Herbert W. Hethcote · SIAM Review · 2000 · 6.9K citations
Stephen A. Lauer, Kyra H. Grantz, Qifang Bi et al. · Annals of Internal Medicine · 2020 · 6.6K citations · Full text
Veterinary Medicine, Infectious Disease Control, Infectious Diseases +17