Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Paul C. Tumeh, Christina L. Harview, Jennifer H. Yearley et al. · Nature · 2014 · 6.5K citations · Full text

Medicine, Immunology, Tumor Immunity +6

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Jérôme Galon, Anne Costes, Fátima Sánchez‐Cabo et al. · Science · 2006 · 6.3K citations

Tumor Immunology, Cancer Immunosurveillance, Adaptive Immune Response +12

The prognostic landscape of genes and infiltrating immune cells across human cancers

Andrew J. Gentles, Aaron M. Newman, Chih Long Liu et al. · Nature Medicine · 2015 · 3.2K citations · Full text

Immune Cells, Cancer Immunosurveillance, Tumor Heterogeneity +12

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

Xuefang Cao, Sheng F. Cai, Todd A. Fehniger et al. · Immunity · 2007 · 967 citations · Full text

Cancer Immunosurveillance, Cell Signaling, T-regulatory Cell +11

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

Xingzhe Ma, Enguang Bi, Yong Lu et al. · Cell Metabolism · 2019 · 919 citations · Full text

Tumor Biology, Cancer Immunosurveillance, Immunology +6