Concepedia

IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain

Chengyu Yin, Boyu Liu, Yuanyuan Li, Xiaojie Li, Jie Wang, Ruixiang Chen, Yan Tai, Qiyang Shou, Ping Wang, Xiaomei Shao,

Theranostics · 2020 · 128 citations · 37 references

DOIFull text

Open access

Concepts

Abstract

We demonstrated a previous unidentified role of IL-33/ST2 in mediating pain hypersensitivity and inflammation in a mouse gout model through promoting neutrophil-dependent ROS production and TRPA1 channel activation. Targeting IL-33/ST2 may represent a novel therapeutic approach to ameliorate gout pain and inflammation.

References

37

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Jochen Schmitz, Alexander M. Owyang, Elizabeth R. Oldham et al. · Immunity · 2005 · 3.7K citations · Full text

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IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy

Boyi Liu, Yan Tai, Satyanarayana Achanta et al. · Proceedings of the National Academy of Sciences · 2016 · 321 citations · Full text

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TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain

Boyi Liu, Lu Fan, Shrilatha Balakrishna et al. · Pain · 2013 · 317 citations

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IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy

Waldiceu A. Verri, Fabrício Oliveira Souto, Sílvio M. Vieira et al. · Annals of the Rheumatic Diseases · 2010 · 261 citations

, , +17

Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis

Yi‐Ling Chen, Danuta Gutowska‐Owsiak, Clare S. Hardman et al. · Science Translational Medicine · 2019 · 251 citations

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