Antifungal activity and toxicological parameters of 8‐hydroxyquinoline‐5‐sulfonamides using alternative animal models

Abstract

The increased incidence of Candida infections resistant to antifungals currently available requires acceleration of the discovery of new agents with properties of inhibiting this fungal pathogen. In this study, we have described the antifungal potential and toxicity of two 8-hydroxyquinoline derivatives using in vivo alternative models, and the results confirm their potential to be developed as new drug candidates.