Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas - Concepedia

Concepedia

Publication | Open Access

Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

DOI Full Paper Access

86

Citations

41

References

2020

Year

Sean J. Judge, Morgan Darrow, Steve W Thorpe, Alicia A. Gingrich, Edmond F. O’Donnell, Alyssa Bellini, Ian R. Sturgill, Logan V. Vick, Cordelia Dunai, Kevin Stoffel,

Journal for ImmunoTherapy of Cancer

Abstract

Intratumoral NK and T cells are prognostic in STS, but their activation is marked by significant upregulation of TIGIT. Our data suggest that combined IL-15 and TIGIT blockade may be a promising clinical strategy in STS.

References

	Year	Citations

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