Concepedia

Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis

Zhiwen Liu, Danyi Yang, Jingli Gao, Xiaohong Xiang, Xiaoru Hu, Siyao Li, Wenwen Wu, Juan Cai, Chengyuan Tang, Dongshan Zhang,

Theranostics · 2020 · 128 citations · 34 references

DOIFull text

Open access

Concepts

Abstract

miR-452 is induced via NF-κB in renal tubular cells in septic AKI. The increase of miR-452, especially that in urine, may be an effective biomarker for early detection of AKI in sepsis patients.

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